Abstract
Addition of the cholera toxin B subunit to oral and intranasal proteosome-Shigella flexneri 2a lipopolysaccharide vaccines improved their immunogenicities. Enhancement of anti-O-Shigella immunoglobulin A levels was most evident in lung lavages following oral immunization and in lung and intestinal fluids when suboptimal doses were used with either immunization route.
MeSH terms
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Administration, Intranasal
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Administration, Oral
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Animals
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Bacterial Vaccines / administration & dosage
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Bacterial Vaccines / immunology*
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Cholera Toxin / immunology*
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Female
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Lipopolysaccharides / immunology*
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Mice
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Mice, Inbred BALB C
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Proteolipids
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Shigella flexneri / immunology*
Substances
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Bacterial Vaccines
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Lipopolysaccharides
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Proteolipids
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proteoliposomes
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Cholera Toxin