Bacterial biofilms: influence on the pathogenesis, diagnosis and treatment of urinary tract infections

J Antimicrob Chemother. 1994 May:33 Suppl A:31-41. doi: 10.1093/jac/33.suppl_a.31.


The bacterial biofilm theory which describes bacterial populations in natural and pathogenic ecological systems in terms of a free-floating or 'planktonic' population of bacteria interacting with a more important matrix enclosed 'sessile' population of bacteria associated with or adherent to a surface, may help explain some of the problems linked to our understanding the nature of urinary tract infections. This paper reviews the role of bacterial biofilm formation in catheter-associated infection, prostatitis and struvite (infected stone) calculogenesis stressing, the importance of bacterial biofilms in the pathogenesis, persistence and hence the treatment of urinary tract infection.

Publication types

  • Review

MeSH terms

  • Biofilms / drug effects*
  • Humans
  • Urinary Catheterization / adverse effects
  • Urinary Tract Infections / diagnosis
  • Urinary Tract Infections / microbiology*
  • Urinary Tract Infections / therapy