HLA and prognosis in multiple sclerosis

J Neurol. 1994 May;241(6):385-90. doi: 10.1007/BF02033356.


The patients of a multiple sclerosis (MS) incidence cohort with 25 years of longitudinal follow-up were typed for HLA-DR and DQ. This type of cohort provides reliable data for gene frequencies and prognostic studies. The influence of sampling bias, mainly due to mortality during the long follow-up, was accounted for. A positive association between MS and DR15,DQ6 was confirmed, but this haplotype did not influence prognosis. There was no difference in haplotype frequency between relapsing-remitting and primary chronic progressive MS. DR17,DQ2 was significantly over-represented in the quartile with the most malignant course. The haplotype DR1,DQ5, which was found rather less frequently in MS patients, also tended to be associated with a poorer prognosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • HLA-DQ Antigens / genetics*
  • HLA-DR Antigens / genetics*
  • Haplotypes
  • Humans
  • Life Tables
  • Multiple Sclerosis / genetics*
  • Multiple Sclerosis / immunology*
  • Multiple Sclerosis / mortality
  • Multiple Sclerosis / physiopathology
  • Prognosis


  • HLA-DQ Antigens
  • HLA-DR Antigens