Repeated therapy with monoclonal antibody to tumour necrosis factor alpha (cA2) in patients with rheumatoid arthritis

Lancet. 1994 Oct 22;344(8930):1125-7. doi: 10.1016/s0140-6736(94)90632-7.


Our in-vitro, animal, and early clinical data suggest that tumour necrosis factor alpha (TNF alpha) is an important target for specific biological therapy in rheumatoid arthritis. We report the results of repeated treatment with a chimeric monoclonal antibody to TNF alpha (cA2) in patients having disease flares. 7 patients originally enrolled in an open-label trial completed two to four cycles, each of which was followed by a good clinical response, with median improvements in the swollen-joint count and C-reactive protein exceeding 80%. cA2 may be useful therapy in the control of acute disease flares in rheumatoid arthritis and treatment programmes including cA2 may be effective in the long-term management of this disease.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Monoclonal / administration & dosage*
  • Antibodies, Monoclonal / adverse effects
  • Antibodies, Monoclonal / therapeutic use
  • Arthritis, Rheumatoid / therapy*
  • C-Reactive Protein / analysis
  • Dose-Response Relationship, Immunologic
  • Humans
  • Infliximab
  • Infusions, Intravenous
  • Recurrence
  • Tumor Necrosis Factor-alpha / immunology*


  • Antibodies, Monoclonal
  • Tumor Necrosis Factor-alpha
  • C-Reactive Protein
  • Infliximab