Abstract
The ability of the selective metabotropic glutamate receptor (mGluR) antagonist alpha-methyl-4-carboxyphenylglycine (MCPG) to protect hippocampal CA1 neurons from a hypoxic/hypoglycemic injury was examined. Rat hippocampal slices were exposed to a 4 min hypoxia/hypoglycemia, and the recovery of evoked population spikes was monitored. 500 microM (+)-MCPG exhibited a statistically significant protective effect, whereas the (-)-isomer was ineffective. These data suggest that MCPG-sensitive mGluRs may contribute to hypoxia/hypoglycemia-induced injury in rat hippocampal slices.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Benzoates / pharmacology*
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Glucose / metabolism
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Glycine / analogs & derivatives*
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Glycine / pharmacology
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Hippocampus / cytology*
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Hippocampus / drug effects
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Hypoglycemia / physiopathology*
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Hypoxia / physiopathology*
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In Vitro Techniques
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Neurons / drug effects*
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Oxygen Consumption / drug effects
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Rats
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Rats, Wistar
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Receptors, Metabotropic Glutamate / antagonists & inhibitors*
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Signal Transduction / drug effects
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Stereoisomerism
Substances
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Benzoates
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Receptors, Metabotropic Glutamate
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alpha-methyl-4-carboxyphenylglycine
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Glucose
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Glycine