The metabotropic glutamate receptor antagonist (+)-alpha-methyl-4-carboxyphenylglycine protects hippocampal CA1 neurons of the rat from in vitro hypoxia/hypoglycemia

Neuropharmacology. 1994 May;33(5):715-7. doi: 10.1016/0028-3908(94)90178-3.

Abstract

The ability of the selective metabotropic glutamate receptor (mGluR) antagonist alpha-methyl-4-carboxyphenylglycine (MCPG) to protect hippocampal CA1 neurons from a hypoxic/hypoglycemic injury was examined. Rat hippocampal slices were exposed to a 4 min hypoxia/hypoglycemia, and the recovery of evoked population spikes was monitored. 500 microM (+)-MCPG exhibited a statistically significant protective effect, whereas the (-)-isomer was ineffective. These data suggest that MCPG-sensitive mGluRs may contribute to hypoxia/hypoglycemia-induced injury in rat hippocampal slices.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzoates / pharmacology*
  • Glucose / metabolism
  • Glycine / analogs & derivatives*
  • Glycine / pharmacology
  • Hippocampus / cytology*
  • Hippocampus / drug effects
  • Hypoglycemia / physiopathology*
  • Hypoxia / physiopathology*
  • In Vitro Techniques
  • Neurons / drug effects*
  • Oxygen Consumption / drug effects
  • Rats
  • Rats, Wistar
  • Receptors, Metabotropic Glutamate / antagonists & inhibitors*
  • Signal Transduction / drug effects
  • Stereoisomerism

Substances

  • Benzoates
  • Receptors, Metabotropic Glutamate
  • alpha-methyl-4-carboxyphenylglycine
  • Glucose
  • Glycine