[The microcirculatory activity of Centella asiatica in venous insufficiency. A double-blind study]

Minerva Cardioangiol. 1994 Jun;42(6):299-304.
[Article in Italian]


In 87 patients with chronic venous hypertensive microangiopathy the efficacy of oral FTTCA (Centella asiatica) administered for 60 days was tested. The microcirculatory effects of two dosages (30 mg bid and 60 mg bid) versus placebo was assessed in a double blind study. The compound was well tolerated and no unwanted effects were observed. Microcirculatory parameters--peri-malleolar skin flux at rest (RF) and transcutaneous PO2 and PCO2--improved as did the abnormally increased RF, PCO2 decreased and PO2 increased in comparison with values measured at inclusion. These results confirm the efficacy of FTTCA in venous hypertensive microangiopathy. Furthermore the effects of FTTCA appear to be dose-related.

Publication types

  • Clinical Trial
  • Comparative Study
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Chronic Disease
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Humans
  • Hypertension / drug therapy
  • Hypertension / physiopathology
  • Male
  • Microcirculation / drug effects
  • Middle Aged
  • Plants, Medicinal
  • Postphlebitic Syndrome / drug therapy
  • Postphlebitic Syndrome / physiopathology
  • Skin / blood supply*
  • Triterpenes / therapeutic use*
  • Venous Insufficiency / drug therapy*
  • Venous Insufficiency / physiopathology


  • Triterpenes