The purpose of this study was to examine the extent to which hopefulness mediates the relationship between perceived social support and general well-being in midadolescents. The sample consisted of 99 high school students, aged 15 to 17, all of whom completed the Personal Resource Questionnaire (PRQ85-Part II), a social support measure, the Hopefulness Scale for Adolescents, and the Adolescent General Well-Being Questionnaire in classroom settings. Statistically significant positive correlations were found between perceived social support and general well-being, perceived social support and hopefulness, and hopefulness and general well-being. Hopefulness was a potent mediator in the relationship between perceived social support and general well-being in midadolescents.