The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila

Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10717-21. doi: 10.1073/pnas.91.22.10717.


The Drosophila bric à brac protein and the transcriptional regulators encoded by tramtrack and Broad-Complex contain a highly conserved domain of approximately 115 amino acids, which we have called the BTB domain. We have identified six additional Drosophila genes that encode this domain. Five of these genes are developmentally regulated, and one of them appears to be functionally related to bric à brac. The BTB domain defines a gene family with an estimated 40 members in Drosophila. This domain is found primarily at the N terminus of zinc finger proteins and is evolutionarily conserved from Drosophila to mammals.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Biological Evolution*
  • Chromosome Mapping
  • Codon
  • Consensus Sequence
  • Conserved Sequence*
  • DNA Primers
  • Drosophila / embryology
  • Drosophila / genetics*
  • Embryo, Nonmammalian / physiology
  • Gene Expression Regulation
  • Humans
  • In Situ Hybridization
  • Introns
  • Molecular Sequence Data
  • Multigene Family*
  • Polymerase Chain Reaction
  • Restriction Mapping
  • Sequence Homology, Amino Acid
  • Zinc Fingers / genetics*


  • Codon
  • DNA Primers

Associated data

  • GENBANK/U14399
  • GENBANK/U14400
  • GENBANK/U14401
  • GENBANK/U14402
  • GENBANK/U14403
  • GENBANK/U14404