Successful physostigmine treatment of acute dothiepin intoxication

Pharmazie. 1994 Aug;49(8):614.


We report on a severe intoxication with the tricyclic antidepressant dothiepin. A treatment with a continuous infusion of physostigmine was successful and improved the ventricular arrhythmia. Dothiepin and its active metabolites were determined in plasma and urine by HPLC.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chromatography, High Pressure Liquid
  • Dothiepin / pharmacokinetics
  • Dothiepin / poisoning*
  • Female
  • Humans
  • Physostigmine / therapeutic use*
  • Suicide, Attempted


  • Physostigmine
  • Dothiepin