Safe administration of iron dextran to a patient who reacted to the test dose

South Med J. 1994 Oct;87(10):1010-2. doi: 10.1097/00007611-199410000-00011.


Parenteral iron therapy is infrequently required but generally well tolerated. We present a case in which intravenous iron dextran was successfully given to a patient who had an anaphylactoid reaction to the test dose. After pretreatment with methylprednisolone, diphenhydramine, ephedrine, and dextran 1, 2 g of iron dextran were safely given over several days; pretreatment was administered only on day 1. In the rare cases in which an anaphylactic agent must be given to a patient with a history of a life-threatening reaction to the agent, pretreatment along with slow escalation of dose may allow safe administration of the offending drug.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Anaphylaxis / chemically induced*
  • Anemia, Iron-Deficiency / drug therapy
  • Desensitization, Immunologic / methods*
  • Humans
  • Iron-Dextran Complex / administration & dosage*
  • Iron-Dextran Complex / adverse effects*
  • Iron-Dextran Complex / therapeutic use
  • Male


  • Iron-Dextran Complex