The T genes in embryogenesis

Trends Genet. 1994 Aug;10(8):280-6. doi: 10.1016/0168-9525(90)90011-t.


Since its identification in 1927, the mouse T (Brachyury) locus has been implicated in mesoderm formation and notochord differentiation. Recent work has demonstrated that this gene encodes a putative transcription factor expressed specifically in nascent mesoderm and in the differentiating notochord. Homologous genes have been cloned from the frog Xenopus laevis, the zebrafish Brachydanio rerio and the ascidian Halocynthia roretzi. The T gene is an important tool for elucidating mesoderman and embryonic pattern formation.

Publication types

  • Review

MeSH terms

  • Animals
  • Base Sequence
  • DNA-Binding Proteins / genetics*
  • Embryonic Induction / genetics*
  • Embryonic and Fetal Development / genetics*
  • Fetal Proteins / genetics*
  • Gene Expression Regulation, Developmental*
  • Mesoderm / physiology*
  • Mice
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid
  • T-Box Domain Proteins*


  • DNA-Binding Proteins
  • Fetal Proteins
  • T-Box Domain Proteins
  • Brachyury protein