Effect of pancreas and kidney transplantation on the neuropathic profile in insulin-dependent diabetics with end-stage nephropathy

Acta Neurol Scand. 1994 Jul;90(1):5-9. doi: 10.1111/j.1600-0404.1994.tb02672.x.

Abstract

From a series of 26 diabetics selected for combined pancreas and kidney transplantations 9 died before surgery was scheduled, one died after surgery and 4 rejected the transplants. The effect of pancreas or kidney transplantation or both on vibratory perception and thermal thresholds, various motor and sensory conduction parameters were studied in 9 of the remaining 12 patients. In 6 both the pancreatic and renal grafts were functioning, in 2 the pancreas was rejected, and in 1 the kidney. At an average follow-up of 41 months after surgery, the mean total score of clinical and electrophysiological improvement in 6 patients with successful combined transplantation was 5.5 +/- 1.6 compared with -4.3 +/- 2.5 in 3 patients with one surviving transplant (P < 0.001). Similarly, the average increase in nerve conduction velocity was 5.8 +/- 1.1 m/s in patients with two functioning grafts whereas it decreased 2.9 +/- 0.7 m/s in those with only one (P < 0.001). The quality of life was considered improved in patients with successful outcome of the two organ transplantations in contrast to the statements of those with only one.

MeSH terms

  • Autonomic Nervous System / physiopathology*
  • Diabetes Mellitus, Type 1 / physiopathology
  • Diabetes Mellitus, Type 1 / surgery*
  • Diabetic Nephropathies / physiopathology
  • Diabetic Nephropathies / surgery*
  • Evoked Potentials
  • Female
  • Follow-Up Studies
  • Graft Rejection
  • Heart Rate / physiology
  • Humans
  • Kidney Failure, Chronic / physiopathology
  • Kidney Failure, Chronic / surgery*
  • Kidney Transplantation / physiology*
  • Male
  • Neural Conduction / physiology
  • Pancreas Transplantation / physiology*
  • Peripheral Nervous System Diseases / diagnosis
  • Peripheral Nervous System Diseases / prevention & control*
  • Quality of Life
  • Sensory Thresholds
  • Thermosensing
  • Vibration