Objective: The aim of the present study was to assess the prevalence of Helicobacter pylori infection in Chinese patients with advanced gastric cancer, to compare this with a matched control population, and to identify factors that may effect the detection of H. pylori in patients with gastric cancer.
Methods: Fifty-one patients with advanced gastric cancer and 102 age/sex-matched controls were included in the study. For the detection of H. pylori, both biopsy specimens and sera were collected from the patients, whereas only sera were collected from the controls. A strong association was shown between H. pylori and both intestinal and diffuse type gastric cancer. Antibiotic intake in the month before endoscopic examination, the site of collection of biopsy specimens, and tumor size were identified as factors that may reduce the histological detection of H. pylori in gastric cancer patients.
Conclusions: These data provide supporting evidence of an association between H. pylori infection and gastric cancer and indicate that, in certain circumstances, histological evaluation of H. pylori infection in gastric cancer cases may be less reliable than serological evaluation.