The power of interval mapping of quantitative trait loci, using selected sib pairs

Am J Hum Genet. 1994 Oct;55(4):825-33.

Abstract

The interval-mapping procedure of Fulker and Cardon for analysis of a quantitative-trait loci (QTL) is extended for application to selected samples of sib pairs. Phenotypic selection of sib pairs, which is known to yield striking increases in power when a single marker is used, provides further increases in power when the interval-mapping approach is used. The greatest benefits of the combined approach are apparent with coarse maps, where QTLs of relatively modest (15%-20%) heritability can be detected with widely spaced markers (40-60 cM apart) in reasonably sized sibling samples. Useful information concerning QTL location is afforded by interval mapping in both selected and unselected samples.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Algorithms
  • Alleles
  • Gene Frequency
  • Genes, Recessive
  • Genetic Carrier Screening
  • Genetics, Medical / methods*
  • Genotype
  • Humans
  • Mathematics
  • Models, Genetic*