Oval defect in detached posterior hyaloid membrane in idiopathic preretinal macular fibrosis

Am J Ophthalmol. 1994 Oct 15;118(4):451-6. doi: 10.1016/s0002-9394(14)75795-2.


We examined the vitreous of 71 eyes with idiopathic preretinal macular fibrosis and observed complete posterior vitreous detachment in 48 eyes (68%), partial posterior vitreous detachment in 16 eyes (22%), and no posterior vitreous detachment in seven eyes (10%). Among the 48 eyes with posterior vitreous detachment, we observed that the detached posterior hyaloid membrane had an oval or round defect in 31 eyes (65%) and a break in the premacular area in 12 eyes (25%). The size and the contour of the premacular defects in the posterior hyaloid membrane corresponded to those characteristic of premacular fibrosis. A premacular oval defect in the detached posterior hyaloid membrane indicates that the vitreous cortex is a structural component of idiopathic premacular fibrosis. We postulate that the thin, premacular vitreous cortex, which forms the posterior wall of the premacular liquefied pocket, plays a key role in the development of idiopathic preretinal macular fibrosis in eyes with or without posterior vitreous detachment.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Eye Diseases / pathology
  • Female
  • Fibrosis
  • Fundus Oculi
  • Humans
  • Macula Lutea / pathology*
  • Male
  • Middle Aged
  • Vitreous Body / pathology*