Defibrination with ancrod in nephrotoxic nephritis in rabbits

Kidney Int. 1976 Nov;10(5):343-7. doi: 10.1038/ki.1976.120.

Abstract

Defibrination with ancrod in nephrotoxic nephritis in rabbits. In rabbits with nephrotoxic nephritis, defibrination with ancrod provided protection when administered during the autologous phase, after extensive glomerular fibrin deposition had occurred and crescents and renal failure were developing. When further glomerular fibrin deposition was prevented by defibrination, deposited fibrin was rapidly removed, indicating that glomerular fibrin-clearing mechanisms are retained in crescentic nephritis. Defibrination had no effect on the extent of glomerular C3 deposition or on the amount of proteinuria.

MeSH terms

  • Ancrod / therapeutic use*
  • Animals
  • Basement Membrane / immunology
  • Complement C3 / analysis
  • Creatinine / blood
  • Disease Models, Animal
  • Endopeptidases / therapeutic use*
  • Fibrin / analysis
  • Fibrinolysis / drug effects*
  • Fluorescent Antibody Technique
  • Immune Sera
  • Immunoglobulin G / analysis
  • Kidney Glomerulus / immunology
  • Male
  • Nephritis / drug therapy*
  • Nephritis / immunology
  • Rabbits

Substances

  • Complement C3
  • Immune Sera
  • Immunoglobulin G
  • Fibrin
  • Creatinine
  • Endopeptidases
  • Ancrod