A comprehensive review of naloxone for the emergency physician

Am J Emerg Med. 1994 Nov;12(6):650-60. doi: 10.1016/0735-6757(94)90033-7.


Naloxone has enjoyed long-standing success as a safe and effective opioid antagonist and has been invaluable in defining the role of endogenous opioid pathways in the response to pathological states such as sepsis and hypovolemia. We look forward to exciting research to further elucidate these pathways and to improve outcome by modulating the patient's physiological response to these stresses.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Adult
  • Animals
  • Asphyxia Neonatorum / drug therapy
  • Cerebrovascular Disorders / drug therapy
  • Child
  • Emergency Medicine / methods*
  • Humans
  • Infant, Newborn
  • Naloxone / pharmacology
  • Naloxone / therapeutic use*
  • Poisoning / drug therapy
  • Shock / drug therapy
  • Spinal Cord Injuries / drug therapy
  • Treatment Outcome


  • Naloxone