Probing the active site and mechanism of action of O6-methylguanine-DNA methyltransferase with substrate analogues (O6-substituted guanines)

Anticancer Drug Des. 1994 Oct;9(5):401-8.
No abstract available

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Binding Sites / drug effects
  • Cattle
  • Colorectal Neoplasms / enzymology
  • Enzyme Activation / drug effects
  • Guanine / analogs & derivatives*
  • Guanine / chemical synthesis
  • Guanine / pharmacology
  • Humans
  • Methyltransferases / drug effects*
  • Methyltransferases / metabolism*
  • Molecular Sequence Data
  • O(6)-Methylguanine-DNA Methyltransferase
  • Structure-Activity Relationship

Substances

  • Guanine
  • Methyltransferases
  • O(6)-Methylguanine-DNA Methyltransferase