Molecular and functional aspects of PECAM-1/CD31

Immunol Today. 1994 Oct;15(10):490-5. doi: 10.1016/0167-5699(94)90195-3.


Among vascular cell adhesion molecules, platelet-endothelial cell adhesion molecule (PECAM-1/CD31) has the distinctive feature of being expressed on several of the major cell types associated with the vascular compartment. This makes it uniquely positioned to mediate multiple and important cell-cell interactions involving platelets, leukocytes and endothelial cells. Thus, PECAM-1 may represent a potential target for new therapeutic agents directed at a variety of pathological states.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alternative Splicing
  • Animals
  • Antibodies, Monoclonal / immunology
  • Antigens, Differentiation, Myelomonocytic / biosynthesis
  • Antigens, Differentiation, Myelomonocytic / chemistry
  • Antigens, Differentiation, Myelomonocytic / genetics
  • Antigens, Differentiation, Myelomonocytic / immunology
  • Antigens, Differentiation, Myelomonocytic / physiology*
  • Cell Adhesion / immunology
  • Cell Adhesion Molecules / biosynthesis
  • Cell Adhesion Molecules / chemistry
  • Cell Adhesion Molecules / genetics
  • Cell Adhesion Molecules / immunology
  • Cell Adhesion Molecules / physiology*
  • Fluorescent Antibody Technique
  • Humans
  • Platelet Endothelial Cell Adhesion Molecule-1


  • Antibodies, Monoclonal
  • Antigens, Differentiation, Myelomonocytic
  • Cell Adhesion Molecules
  • Platelet Endothelial Cell Adhesion Molecule-1