The B-cell antigen receptor complex: structure and signal transduction

C M Pleiman; D D'Ambrosio; J C Cambier

doi:10.1016/0167-5699(94)90267-4

The B-cell antigen receptor complex: structure and signal transduction

Immunol Today. 1994 Sep;15(9):393-9. doi: 10.1016/0167-5699(94)90267-4.

Authors

C M Pleiman¹, D D'Ambrosio, J C Cambier

Affiliation

¹ National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80220.

PMID: 7945780
DOI: 10.1016/0167-5699(94)90267-4

Abstract

The specificity of the immune response is determined by the interaction between the B-cell receptor (BCR) and its cognate structure, antigen. Recent studies have provided considerable insight into the compartmentalization of function within this extremely versatile hetero-oligomeric receptor complex. In this article, Christopher Pleiman, Daniele D'Ambrosio and John Cambier consolidate new findings regarding BCR structure and signal transduction.

Publication types

Review

MeSH terms

Amino Acid Sequence
Animals
Enzyme Precursors / immunology
Humans
Intracellular Signaling Peptides and Proteins
Molecular Sequence Data
Protein-Tyrosine Kinases / immunology
Receptors, Antigen, B-Cell / chemistry
Receptors, Antigen, B-Cell / immunology*
Signal Transduction / immunology*
Syk Kinase

Substances

Enzyme Precursors
Intracellular Signaling Peptides and Proteins
Receptors, Antigen, B-Cell
Protein-Tyrosine Kinases
SYK protein, human
Syk Kinase