The B-cell antigen receptor complex: structure and signal transduction

Immunol Today. 1994 Sep;15(9):393-9. doi: 10.1016/0167-5699(94)90267-4.


The specificity of the immune response is determined by the interaction between the B-cell receptor (BCR) and its cognate structure, antigen. Recent studies have provided considerable insight into the compartmentalization of function within this extremely versatile hetero-oligomeric receptor complex. In this article, Christopher Pleiman, Daniele D'Ambrosio and John Cambier consolidate new findings regarding BCR structure and signal transduction.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Enzyme Precursors / immunology
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Molecular Sequence Data
  • Protein-Tyrosine Kinases / immunology
  • Receptors, Antigen, B-Cell / chemistry
  • Receptors, Antigen, B-Cell / immunology*
  • Signal Transduction / immunology*
  • Syk Kinase


  • Enzyme Precursors
  • Intracellular Signaling Peptides and Proteins
  • Receptors, Antigen, B-Cell
  • Protein-Tyrosine Kinases
  • SYK protein, human
  • Syk Kinase