Abstract
Accessory molecules play an important role in the regulation of lymphocyte activation mediated by the B-cell antigen receptor (BCR). CD22 is one such accessory molecule expressed on B-lineage cells. Here, Che-Leung Law and colleagues review current knowledge on the structure-function relationship between CD22 and the BCR, discuss the role of CD22 as a cell-adhesion molecule and suggest models for potential in vivo functions of CD22.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Animals
-
Antigens, CD / biosynthesis
-
Antigens, CD / immunology*
-
Antigens, Differentiation, B-Lymphocyte / biosynthesis
-
Antigens, Differentiation, B-Lymphocyte / immunology*
-
B-Lymphocytes / immunology
-
Calcium / metabolism
-
Cell Adhesion Molecules / immunology
-
Humans
-
Lectins*
-
Lymphocyte Activation / immunology*
-
Sialic Acid Binding Ig-like Lectin 2
-
Signal Transduction / immunology
Substances
-
Antigens, CD
-
Antigens, Differentiation, B-Lymphocyte
-
CD22 protein, human
-
Cell Adhesion Molecules
-
Lectins
-
Sialic Acid Binding Ig-like Lectin 2
-
Calcium