Aortic graft infection represents one of the most formidable challenges encountered by the vascular surgeon. Current principles of treatment are based on experience primarily derived from infection with Staphylococcus and enteric bacteria. Anaerobic prosthetic infection is a case event. Infection with Clostridium has heretofore been reported only twice. An additional case of clostridial infection of an aortic prosthesis is presented with review of the literature. Its clinical significance and management are discussed.