Neurological illness following treatment with fludarabine

Br J Cancer. 1994 Nov;70(5):966-8. doi: 10.1038/bjc.1994.430.


Fludarabine is a comparatively new drug for the treatment of low-grade lymphoid malignancy. This report describes five cases of unusual neurological illnesses occurring after treatment with fludarabine. These suggest that caution should be exercised in patients receiving fludarabine who develop neurological abnormalities, with prompt investigation and if necessary cessation of the drug.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Lymphoma, Non-Hodgkin / drug therapy
  • Male
  • Middle Aged
  • Nervous System Diseases / chemically induced*
  • Vidarabine / adverse effects
  • Vidarabine / analogs & derivatives*
  • Vidarabine / therapeutic use


  • Antineoplastic Agents
  • Vidarabine
  • fludarabine