Effect of topical calcipotriol on congenital ichthyoses

Br J Dermatol. 1994 Oct;131(4):546-50. doi: 10.1111/j.1365-2133.1994.tb08558.x.


We investigated the clinical efficacy of topically applied calcipotriol in six patients with congenital ichthyosis, using a double-blind, bilaterally paired, comparative approach. Unilateral improvement, in favour of the calcipotriol-treated side, was observed in three patients with lamellar ichthyosis. A beneficial response was also observed in a patient with bullous ichthyotic erythroderma of Brocq. No clinical side-effects or laboratory anomalies were observed. This study indicates that calcipotriol constitutes a new and promising approach in alleviating disorders of keratinization characterized by hyperproliferation, other than psoriasis.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Administration, Cutaneous
  • Adolescent
  • Adult
  • Calcitriol / administration & dosage
  • Calcitriol / analogs & derivatives*
  • Dermatologic Agents / administration & dosage*
  • Double-Blind Method
  • Excipients / administration & dosage
  • Female
  • Humans
  • Ichthyosis / drug therapy*
  • Male
  • Middle Aged
  • Prospective Studies
  • Skin / drug effects


  • Dermatologic Agents
  • Excipients
  • calcipotriene
  • Calcitriol