P nucleotides, hairpin DNA and V(D)J joining: making the connection

Semin Immunol. 1994 Jun;6(3):131-41. doi: 10.1006/smim.1994.1019.


The fine-structures of V(D)J joining products present a cache of information about the recombination process. Testable hypotheses with predictive value are beginning to provide a surprisingly detailed picture of the joining operation. Here, one feature of V(D)J junctions, the appearance of short palindromic inserts, is discussed, and experimental evidence in support of a joining model involving a hairpin-terminated DNA intermediate will be summarized.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Base Sequence
  • DNA / chemistry
  • DNA / genetics*
  • Gene Rearrangement / genetics*
  • Molecular Sequence Data
  • Nucleic Acid Conformation*
  • Receptors, Antigen / genetics*
  • Recombination, Genetic


  • Receptors, Antigen
  • DNA