Transient neonatal diabetes mellitus: a relapse after 10 years of complete remission

Acta Diabetol. 1994 Jun;31(2):116-8. doi: 10.1007/BF00570547.


The follow-up study of a patient with permanent diabetes (DM) unrelated to islet cell antibody and anti-insulin antibodies and occurring 10 years after a transient neonatal DM episode is reported. A latent defect in insulin release was proved. It produced transient glucosuria during intercurrent illnesses and permanent hyperglycaemia and a decrease in growth velocity [with high stimulated growth hormone and low insulin-like growth factor I (IGF-I)] at the onset of puberty. After insulin therapy was re-introduced, catch-up growth and normalization of the blood glucose and IGF-I levels were noted.

Publication types

  • Case Reports

MeSH terms

  • Autoantibodies / blood
  • Birth Weight
  • Blood Glucose / metabolism
  • Diabetes Mellitus, Type 1 / drug therapy
  • Diabetes Mellitus, Type 1 / physiopathology*
  • Female
  • Follow-Up Studies
  • Glycated Hemoglobin / analysis
  • Glycosuria
  • Growth
  • Humans
  • Insulin / therapeutic use
  • Islets of Langerhans / immunology
  • Male
  • Recurrence
  • Remission, Spontaneous


  • Autoantibodies
  • Blood Glucose
  • Glycated Hemoglobin A
  • Insulin
  • islet cell antibody