HLA-antigen b27 in cases with joint affections in an outbreak of salmonellosis

Scand J Infect Dis. 1976;8(4):245-8. doi: 10.3109/inf.1976.8.issue-4.05.


An outbreak of infection with Salmonella typhi murium occurred in southern Sweden in the summer of 1974. About 330 persons were infected; 91 were hospitalized. 13 of the 91 patients (9 men and 4 women) had symptoms of aseptical polyarthritis. The 13 patients with arthritis were HLA typed with a standard microlymphocytotoxicity test. 13 salmonellosis patients from the same epidemic but without arthritis and 446 healthy blood donors served as controls. Nine (69%) of the 13 patients with arthritis had HLA-B27 compared to 1 (8%) of the control patients and 44 (10%) of the blood donors. The observed association between HLA antigen B27 and reactive arthropathy following salmonella infection could be due to a function of a disease predisposing gene closely linked to HLA-B27.

MeSH terms

  • Adolescent
  • Adult
  • Arthritis / etiology
  • Arthritis / immunology*
  • Female
  • HLA Antigens*
  • Histocompatibility Antigens*
  • Humans
  • Male
  • Middle Aged
  • Salmonella Infections / complications
  • Salmonella Infections / immunology*
  • Salmonella typhimurium


  • HLA Antigens
  • Histocompatibility Antigens