Dorsoventral patterning in Drosophila oogenesis

Curr Opin Genet Dev. 1994 Aug;4(4):502-7. doi: 10.1016/0959-437x(94)90064-a.

Abstract

Dorsoventral polarity in the egg chamber of Drosophila involves the localization of maternal gurken RNA to the dorsal side of the oocyte. The gurken protein has homology to secreted growth factors and may bind to the torpedo/DER receptor tyrosine kinase present on the adjacent follicle cells. This localized signal from the oocyte to the follicle cells appears to initiate a cascade of events leading to dorsal follicle cell differentiation, and delimiting and orienting the future dorsoventral axis of the embryo.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Polarity
  • Drosophila / embryology*
  • Drosophila / genetics
  • Drosophila Proteins*
  • Embryo, Nonmammalian / physiology
  • Embryonic Induction / genetics
  • Female
  • Gene Expression Regulation, Developmental*
  • Genes, Insect
  • Insect Hormones / metabolism*
  • Larva / physiology
  • Morphogenesis / genetics
  • Oocytes / metabolism
  • Oogenesis / physiology*
  • Ovary / cytology
  • RNA, Messenger / metabolism
  • Receptor Protein-Tyrosine Kinases / metabolism
  • Signal Transduction / physiology*
  • Transforming Growth Factor alpha*
  • Transforming Growth Factors / metabolism*

Substances

  • Drosophila Proteins
  • Insect Hormones
  • RNA, Messenger
  • Transforming Growth Factor alpha
  • grk protein, Drosophila
  • Transforming Growth Factors
  • Receptor Protein-Tyrosine Kinases