Abstract
Programmed cell death in the nematode Caenorhabditis elegans requires the activities of the genes ced-3 and ced-4 and is antagonized by the activity of the gene ced-9. Cloning of these C. elegans genes has shown that two of them encode proteins with similarity to vertebrate cell death genes and has revealed that nematodes and mammals share a common pathway for programmed cell death.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Apoptosis / genetics*
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Apoptosis Regulatory Proteins
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Caenorhabditis elegans / genetics*
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Caenorhabditis elegans / physiology*
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Caenorhabditis elegans Proteins*
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Calcium-Binding Proteins / genetics
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Calcium-Binding Proteins / physiology
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Caspases*
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Consensus Sequence
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Cysteine Proteinase Inhibitors / genetics
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Genes, Helminth*
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Genes, Viral
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Helminth Proteins / genetics
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Helminth Proteins / physiology
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Molecular Sequence Data
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Proto-Oncogene Proteins / genetics
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Proto-Oncogene Proteins / physiology
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Proto-Oncogene Proteins c-bcl-2
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Sequence Homology, Amino Acid
Substances
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Apoptosis Regulatory Proteins
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Caenorhabditis elegans Proteins
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Calcium-Binding Proteins
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Ced-4 protein, C elegans
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Ced-9 protein, C elegans
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Cysteine Proteinase Inhibitors
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Helminth Proteins
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-bcl-2
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Caspases
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ced-3 protein, C elegans