Axon guidance by diffusible repellants and attractants

Curr Opin Genet Dev. 1994 Aug;4(4):596-601. doi: 10.1016/0959-437x(94)90078-h.


Diffusible guidance cues are now understood to play an important role in axon guidance. The past year saw the first evidence for long-range chemorepulsion of axons, and the identification of a diffusible growth cone collapse-inducing protein, collapsin. Evidence was obtained against a chemoattractant role for nerve growth factor in vivo. A neurotransmitter, acetylcholine, was shown to be capable of acting as a diffusible attractant, but, as with nerve growth factor, whether it has this function in vivo is unknown.

Publication types

  • Review

MeSH terms

  • Acetylcholine / physiology
  • Animals
  • Axons / physiology*
  • Cell Movement / physiology
  • Cells, Cultured
  • Chemotactic Factors / physiology*
  • Glycoproteins / physiology
  • Nerve Growth Factors / physiology*
  • Nervous System / embryology*
  • Olfactory Bulb / embryology
  • Receptors, Growth Factor / physiology
  • Semaphorin-3A
  • Spinal Cord / embryology
  • Tropism


  • Chemotactic Factors
  • Glycoproteins
  • Nerve Growth Factors
  • Receptors, Growth Factor
  • Semaphorin-3A
  • Acetylcholine