IL-5 and its receptor: which role do they play in the immune response?

Int Arch Allergy Immunol. 1994 May;104(1):1-9. doi: 10.1159/000236702.


IL-5 is a homodimeric glycoprotein that promotes proliferation and differentiation of activated B cells, and controls the production and functions of some other hematopoietic cells, such as Ly-1(CD5)+ B cells, eosinophils and basophils. In humans, IL-5 acts as a differentiation and growth factor for eosinophils, and is the major cytokine involved in the production of eosinophilia. IL-5 acts on its target cells through the specific receptor that is composed of two polypeptide chains, a and b. The alpha-chain is unique to IL-5, while the beta-chain is common to IL-5 receptor, IL-3 receptor and granulocyte-macrophage colony stimulating factor (GM-CSF) receptor.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Eosinophils / immunology
  • Humans
  • Interleukin-5 / biosynthesis
  • Interleukin-5 / chemistry
  • Interleukin-5 / immunology*
  • Mice
  • Molecular Sequence Data
  • Receptors, Interleukin / biosynthesis
  • Receptors, Interleukin / chemistry
  • Receptors, Interleukin / immunology*
  • Receptors, Interleukin-5


  • Interleukin-5
  • Receptors, Interleukin
  • Receptors, Interleukin-5