This study investigated the relationship between brain injury and personality, using the Luria-Nebraska Neuropsychological Battery and the Clinical Analysis Questionnaire as measurement tools. Psychopathological factors, as opposed to normal personality traits, were highly correlated with measures of brain injury. Depression, in particular, was found to be substantially involved in the sequelae of brain injury for this sample. A trend in the data revealed that suicidal depression and anxious depression were differentially related to deficits on two scales of the LNNB. Patients with evidence of suicidal depression were also more sensitive to emotional dysfunction in other areas. Few differences were found between patients with traumatic brain injury and those with other types of brain injuries. Results suggest that measures of psychopathology can provide important supplementary information to neuropsychological assessment, above that obtained from measures of brain functioning alone. Controlled studies should investigate the relationship between psychopathology and neuropsychology more thoroughly to provide clearer determinations of its involvement in the rehabilitation of the brain-injured person.