Sex hormones and lipoprotein metabolism

Curr Opin Lipidol. 1994 Jun;5(3):236-40. doi: 10.1097/00041433-199405030-00012.


Previous findings of increased production of large VLDL particles by estrogen have been confirmed in a trial using estrogen-dominant oral contraceptives. Estrogen has been found to have LDL subclass-specific effects and to shift the distribution of apolipoprotein (apo)E from HDL to VLDL. Several recent studies document decreases in lipoprotein (a) [Lp(a)] levels, but the metabolic mechanism is yet unknown. The effects of progestational agents on lipoprotein metabolism remain unclear in view of conflicting reports.

Publication types

  • Review

MeSH terms

  • Androgens / pharmacology
  • Animals
  • Apolipoproteins B / pharmacology
  • Estrogens / pharmacology
  • Female
  • Gonadal Steroid Hormones / pharmacology*
  • Humans
  • Lipoproteins / metabolism*
  • Male
  • Mice
  • Progestins / pharmacology


  • Androgens
  • Apolipoproteins B
  • Estrogens
  • Gonadal Steroid Hormones
  • Lipoproteins
  • Progestins