Pathobiology of intimal hyperplasia

Br J Surg. 1994 Sep;81(9):1254-69. doi: 10.1002/bjs.1800810904.


In the current vascular interventional environment, high restenosis rates have increased awareness of the significance of intimal hyperplasia, a chronic structural lesion that develops after vessel wall injury, and which can lead to luminal stenosis and occlusion. Intimal hyperplasia may be defined as the abnormal migration and proliferation of vascular smooth muscle cells with associated deposition of extracellular connective tissue matrix. The pathology of intimal hyperplasia is reviewed with particular attention to its physiology, pharmacology, cell biology and molecular biology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Blood Platelets / physiology
  • Humans
  • Hyperplasia
  • Leukocytes / physiology
  • Muscle Contraction
  • Muscle, Smooth, Vascular / pathology*
  • Platelet-Derived Growth Factor / physiology
  • Signal Transduction
  • Transforming Growth Factor alpha / physiology
  • Tunica Intima / pathology*


  • Platelet-Derived Growth Factor
  • Transforming Growth Factor alpha