Inducing factors in Xenopus early embryos

Curr Biol. 1994 Feb 1;4(2):116-26. doi: 10.1016/s0960-9822(94)00027-8.


Recent results make it possible to postulate credible candidates for each of the known inducing signals that act to determine cell fate during Xenopus early development. Experiments on biological activity, expression patterns and inhibition of function suggest that Vg-1 and Wnt-11 may act as the primary mesoderm-inducing signals, FGF and activin may serve to relay their effects, and noggin may be a major component of the dorsalizing and neural-inducing signals from the organizer.

Publication types

  • Review

MeSH terms

  • Activins
  • Animals
  • Blastocyst / physiology
  • Embryo, Nonmammalian / physiology*
  • Female
  • Fertilization
  • Fibroblast Growth Factors / physiology
  • Gastrula / physiology
  • Inhibins / physiology
  • Mesoderm / physiology
  • Models, Biological
  • Nervous System / embryology
  • RNA, Messenger / physiology
  • Signal Transduction
  • Xenopus / embryology*
  • Xenopus laevis / embryology


  • RNA, Messenger
  • Activins
  • Inhibins
  • Fibroblast Growth Factors