Immunodeficiency viruses. Not enough sans Nef

Curr Biol. 1994 Jul 1;4(7):618-20. doi: 10.1016/s0960-9822(00)00135-4.

Abstract

The nef genes of HIV and SIV are dispensable in vitro, but are essential for viral spread and disease progression in vivo. Nef-induced down-regulation of CD4, the viral receptor, may be the key to this requirement.

Publication types

  • Review

MeSH terms

  • Animals
  • CD4 Antigens / biosynthesis*
  • CD4 Antigens / genetics
  • CD4-Positive T-Lymphocytes / metabolism
  • CD4-Positive T-Lymphocytes / microbiology
  • Cells, Cultured
  • Down-Regulation
  • Gene Products, nef / genetics
  • Gene Products, nef / physiology*
  • Genes, nef*
  • HIV / genetics*
  • HIV / pathogenicity
  • HIV / physiology
  • Haplorhini
  • Humans
  • Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
  • Mice
  • Mice, SCID
  • Mice, Transgenic
  • Proto-Oncogene Proteins / physiology
  • Simian Immunodeficiency Virus / genetics*
  • Simian Immunodeficiency Virus / pathogenicity
  • Simian Immunodeficiency Virus / physiology
  • Virus Replication* / genetics
  • nef Gene Products, Human Immunodeficiency Virus

Substances

  • CD4 Antigens
  • Gene Products, nef
  • Proto-Oncogene Proteins
  • nef Gene Products, Human Immunodeficiency Virus
  • Lymphocyte Specific Protein Tyrosine Kinase p56(lck)