Abstract
The nef genes of HIV and SIV are dispensable in vitro, but are essential for viral spread and disease progression in vivo. Nef-induced down-regulation of CD4, the viral receptor, may be the key to this requirement.
MeSH terms
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Animals
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CD4 Antigens / biosynthesis*
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CD4 Antigens / genetics
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CD4-Positive T-Lymphocytes / metabolism
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CD4-Positive T-Lymphocytes / microbiology
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Cells, Cultured
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Down-Regulation
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Gene Products, nef / genetics
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Gene Products, nef / physiology*
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Genes, nef*
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HIV / genetics*
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HIV / pathogenicity
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HIV / physiology
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Haplorhini
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Humans
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Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
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Mice
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Mice, SCID
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Mice, Transgenic
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Proto-Oncogene Proteins / physiology
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Simian Immunodeficiency Virus / genetics*
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Simian Immunodeficiency Virus / pathogenicity
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Simian Immunodeficiency Virus / physiology
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Virus Replication* / genetics
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nef Gene Products, Human Immunodeficiency Virus
Substances
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CD4 Antigens
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Gene Products, nef
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Proto-Oncogene Proteins
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nef Gene Products, Human Immunodeficiency Virus
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Lymphocyte Specific Protein Tyrosine Kinase p56(lck)