Axis determination. Proteolytic generation of a morphogen

Curr Biol. 1994 Aug 1;4(8):755-7. doi: 10.1016/s0960-9822(00)00170-6.

Abstract

Ventral activation of a transmembrane receptor, Toll, is a crucial step in dorsoventral axis establishment in Drosophila embryos. The ventral ligand for Toll seems to be a proteolytic fragment of the Spätzle protein.

Publication types

  • Review

MeSH terms

  • Animals
  • Drosophila / embryology*
  • Drosophila Proteins*
  • Embryonic Development
  • Gastrula / physiology
  • Gene Expression Regulation
  • Insect Hormones / physiology*
  • Insect Proteins*
  • Membrane Glycoproteins / physiology*
  • Models, Biological
  • Morphogenesis
  • Receptors, Cell Surface / physiology
  • Serine Endopeptidases / physiology*
  • Toll-Like Receptors

Substances

  • Drosophila Proteins
  • Insect Hormones
  • Insect Proteins
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Tl protein, Drosophila
  • Toll-Like Receptors
  • spz protein, Drosophila
  • Serine Endopeptidases
  • ea protein, Drosophila
  • snk protein, Drosophila