Distal accentuation of conduction slowing in polyneuropathy associated with antibodies to myelin-associated glycoprotein and sulphated glucuronyl paragloboside

Brain. 1994 Oct;117 ( Pt 5):941-7. doi: 10.1093/brain/117.5.941.


In four patients with a chronic, demyelinating polyneuropathy associated with monoclonal IgM antibodies to myelin-associated glycoprotein (MAG) and sulphated glucuronyl paragloboside (SGPG), we have observed a marked prolongation of distal motor latencies disproportionate to proximal segment-conduction velocities, in nearly all nerves studied. Distal accentuation of conduction slowing distinguished these patients from those with Charcot-Marie-Tooth polyneuropathy type 1A, chronic inflammatory polyneuropathy, and from controls, as demonstrated by regression of distal motor latency on proximal conduction velocity. Sixteen of 21 nerves (76%) studied in the patients with anti-MAG/SGPG polyneuropathy had a terminal latency index of < or = 0.25 versus 11 of 195 nerves (6%) of Charcot-Marie-Tooth polyneuropathy type 1A patients, three of 49 nerves (6%) of patients with chronic inflammatory polyneuropathy and none of the controls (P = 0.0001). Recognition of this unique pattern of generalized, distally predominant conduction slowing in anti-MAG/SGPG polyneuropathy may be useful in clinically distinguishing this from other chronic demyelinating polyneuropathies, and in possibly providing insights into the pathophysiology of this disorder.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antibodies / analysis*
  • Female
  • Globosides / immunology*
  • Humans
  • Male
  • Middle Aged
  • Motor Neurons
  • Myelin Proteins / immunology*
  • Neural Conduction*
  • Peripheral Nervous System Diseases / immunology*
  • Peripheral Nervous System Diseases / physiopathology*


  • Antibodies
  • Globosides
  • Myelin Proteins
  • sulfate-3-glucuronyl paragloboside