Rostro-caudal patterning of receptor-expressing olfactory neurones in the rat nasal cavity

Cell Tissue Res. 1994 Oct;278(1):11-20. doi: 10.1007/BF00305773.


The rostro-caudal extent of odorant receptor expression zones in the rat olfactory epithelium was analysed by means of in situ hybridization. Three broad non-overlapping zones were identified that extended along almost the entire anterior-posterior axis; each zone was composed of several separate bands running anterior to posterior throughout the olfactory epithelium. Super-imposed onto these broad zones was the expression area of a particular receptor subtype (OR37); it was restricted to a small region of the epithelial sheet with a high density of reactive neurones in the centre and declining numbers towards the periphery of the region. A quantitative evaluation of the reactive cells revealed that, despite their different distribution patterns, all receptor subtypes were expressed in an equal number of neurones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cloning, Molecular
  • Female
  • In Situ Hybridization
  • Male
  • Multigene Family
  • Nasal Mucosa / cytology*
  • Olfactory Receptor Neurons / ultrastructure*
  • RNA Probes
  • RNA, Antisense
  • Rats
  • Rats, Wistar
  • Receptors, Odorant / analysis*
  • Receptors, Odorant / classification
  • Receptors, Odorant / genetics
  • Recombinant Proteins / genetics


  • RNA Probes
  • RNA, Antisense
  • Receptors, Odorant
  • Recombinant Proteins