Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice

Cell. 1994 Oct 21;79(2):365-75. doi: 10.1016/0092-8674(94)90204-6.


We generated a novel strain of mutant mouse with a deletion in the gene encoding metabotropic glutamate receptor 1 (mGluR1). Gross anatomy of the hippocampus, excitatory synaptic transmission, long-term depression, and short-term potentiation in the hippocampal CA1 region are all apparently normal in the mutant mice. In contrast, long-term potentiation (LTP) is substantially reduced, and a moderate level of impairment is observed in context-specific associative learning. We propose that mGluR1 is not "in line" in LTP production, but rather modulates the plasticity process, and hence affects context-specific associative learning.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • DNA Primers / chemistry
  • Electric Stimulation
  • Female
  • Genes
  • Hippocampus / pathology
  • Hippocampus / physiology*
  • In Vitro Techniques
  • Long-Term Potentiation*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Molecular Sequence Data
  • Neuronal Plasticity
  • Receptors, Glutamate / physiology*
  • Restriction Mapping
  • Synaptic Transmission


  • DNA Primers
  • Receptors, Glutamate