fringe, a Boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development

Cell. 1994 Nov 18;79(4):595-606. doi: 10.1016/0092-8674(94)90545-2.

Abstract

Wing formation in Drosophila requires interactions between dorsal and ventral cells. We describe a new gene, fringe, which is expressed in dorsal cells and encodes for a novel protein that is predicted to be secreted. Wing margin formation and distal wing outgrowth can be induced by the juxtaposition of cells with and without fringe expression, whether at the normal wing margin, at the boundaries of fringe mutant clones in the dorsal wing, or at sites of fringe misexpression in the ventral wing. By contrast, both loss of fringe expression and uniform fringe expression cause wing loss. These observations suggest that fringe encodes a boundary-specific cell-signaling molecule that is responsible for dorsal-ventral cell interactions during wing development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cloning, Molecular
  • Crosses, Genetic
  • Drosophila / genetics
  • Drosophila / physiology*
  • Drosophila Proteins
  • Female
  • Gene Expression
  • Larva
  • Male
  • Molecular Sequence Data
  • Mutagenesis
  • N-Acetylglucosaminyltransferases*
  • Open Reading Frames
  • Phenotype
  • Protein Biosynthesis
  • Proteins / metabolism*
  • Signal Transduction
  • Wings, Animal / cytology
  • Wings, Animal / physiology

Substances

  • Drosophila Proteins
  • Proteins
  • N-Acetylglucosaminyltransferases
  • fng protein, Drosophila

Associated data

  • GENBANK/L35770