Primary anetoderma: phagocytosis of elastic fibres by macrophages

Clin Exp Dermatol. 1994 Sep;19(5):388-90. doi: 10.1111/j.1365-2230.1994.tb02688.x.

Abstract

We report a 22-year-old female with a 2-year history of increasingly numerous well-circumscribed, asymptomatic skin lesions. The clinical and histological features were consistent with anetoderma and investigations failed to reveal any associated underlying disorders. Electron microscopy of abnormal skin showed phagocytosis of elastic fibres by macrophages. Although the aetiology of primary anetoderma remains unknown, this finding suggests that phagocytic destruction of elastic fibres plays a major role in its pathogenesis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Connective Tissue Diseases / etiology
  • Connective Tissue Diseases / pathology
  • Elastic Tissue / ultrastructure*
  • Female
  • Humans
  • Macrophages / physiology*
  • Macrophages / ultrastructure
  • Phagocytosis / physiology*
  • Skin / ultrastructure