Gallbladder ejection fraction. Nondiagnostic for sphincter of Oddi dysfunction in patients with intact gallbladders

Clin Nucl Med. 1994 Aug;19(8):713-9.


Thirty consecutive patients with intact gallbladders and biliary pain were evaluated to determine whether gallbladder ejection fraction could identify sphincter of Oddi dysfunction. The mean gallbladder ejection fraction was 45% in patients with abdominal pain and 72% in normal controls. Gallbladder ejection fractions were then correlated with endoscopically measured sphincter of Oddi pressures in patients with abdominal pain. The mean gallbladder ejection fraction was 41% in 7 patients with elevated sphincter pressures and 46% in 23 patients with normal pressures (P = NS). Thirty-six percent of patients with elevated pressures and 33% of patients with normal pressures had abnormal gallbladder ejection fractions. Gallbladder ejection fraction had a sensitivity of 33%, a specificity of 63%, and a positive predictive value of 25% for detection of elevated pressures. Regression analysis revealed a poor correlation between sphincter pressure and gallbladder ejection fraction (r2 = 0.02). These findings suggest that gallbladder ejection fraction cannot be used to diagnose sphincter of Oddi dysfunction in patients before they undergo cholecystectomy.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Abdominal Pain / etiology
  • Adult
  • Common Bile Duct Diseases / diagnostic imaging
  • Double-Blind Method
  • Female
  • Gallbladder / diagnostic imaging*
  • Gallbladder Emptying / physiology*
  • Humans
  • Imino Acids
  • Male
  • Organotechnetium Compounds
  • Prospective Studies
  • Radionuclide Imaging
  • Regression Analysis
  • Sensitivity and Specificity
  • Sincalide
  • Sphincter of Oddi / diagnostic imaging*
  • Sphincter of Oddi / physiopathology
  • Technetium Tc 99m Disofenin


  • Imino Acids
  • Organotechnetium Compounds
  • Sincalide
  • Technetium Tc 99m Disofenin