Microalbuminuria: prognostic and therapeutic implications in diabetes mellitus

Diabet Med. 1994 Aug-Sep;11(7):636-45. doi: 10.1111/j.1464-5491.1994.tb00325.x.


Thirty years following the development of the first radioimmunoassay for albumin, microalbuminuria is widely acknowledged as an important predictor of overt nephropathy in patients with Type 1 diabetes and of cardiovascular mortality in Type 2 diabetes. In addition, there is accumulating evidence to suggest that diabetic patients with microalbuminuria may have more advanced retinopathy, higher blood pressure, and worse dyslipidaemia than patients with normal albumin excretion rates. Recent studies have focused on the role of intervention, principally with antihypertensive therapy and intensive glycaemic control, in reducing microalbuminuria. While successful in reducing urinary albumin excretion it remains to be established whether such therapies will be translated into a reduction in renal failure and decreased cardiovascular morbidity and mortality.

Publication types

  • Review

MeSH terms

  • Albuminuria* / epidemiology
  • Albuminuria* / physiopathology
  • Blood Glucose / metabolism
  • Blood Pressure
  • Cost-Benefit Analysis
  • Diabetes Mellitus / physiopathology*
  • Diabetes Mellitus / therapy
  • Diabetes Mellitus / urine
  • Diabetic Nephropathies / economics
  • Diabetic Nephropathies / physiopathology*
  • Diabetic Nephropathies / prevention & control
  • Humans
  • Hypertension / complications
  • Hypertension / urine
  • Prognosis
  • United States


  • Blood Glucose