PIP: Belgian dermatologists recently reported what is probably the first case of combined seminal fluid and latex allergy. A young atopic woman presented with the clinical symptoms of swelling and a burning sensation on the vulva and in the vulvovaginal area during or after coitus, followed by vesiculation, lichenification, and generalized eczema. Diagnosis was confirmed by the appropriate testing methods. The author treated a 34-year old nurse who had an immediate type I reaction to seminal fluid documented by results of radioallergosorbent and prick tests. The patient also has an history of contact urticaria due to latex gloves and rubber condoms. Nonrubber condoms, such as Lambskin condoms, made from processed sheep intestines, may be recommended for use by patients with this type of combined allergy. These condoms do not, however, protect against HIV infection. To protect against HIV infection, the male partner must wear a rubber condom with a Lambskin condom over the rubber one to protect his partner from allergy. Otherwise, the female condom may be used, for it is made of nonsensitizing polyurethane. In this case, the doctor gave Tactylon nonlatex synthetic elastomer condoms to the husband. The condoms, yet to be approved by the US Food and Drug Administration, are made by the manufacturer of Tactylon nonlatex gloves. The nurse use the gloves at work without experiencing an allergic reaction.