Disposition of magnolol after intravenous bolus and infusion in rabbits

Drug Metab Dispos. 1994 Jul-Aug;22(4):518-21.


A simple and sensitive high-performance liquid chromatographic method was developed for the determination and identification of magnolol to study its pharmacokinetics in rabbits after a 5 mg/kg i.v. bolus and 76 micrograms/kg/min i.v. infusion. Plasma concentration time profiles were suited to a two-compartment open model. The elimination half-lives of magnolol were 14.56 and 15.71 min, and the total body clearances were 75.86 and 72.72 ml/min/kg for i.v. bolus and i.v. infusion, respectively. There were no significant differences in elimination half-life and total body clearance between i.v. bolus and i.v. infusion, which suggests that magnolol pharmacokinetics are linear.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Biphenyl Compounds / analysis
  • Biphenyl Compounds / blood
  • Biphenyl Compounds / pharmacokinetics*
  • Chromatography, High Pressure Liquid
  • Electrochemistry
  • Infusions, Intravenous
  • Injections, Intravenous
  • Lignans*
  • Male
  • Rabbits
  • Reference Standards
  • Regression Analysis
  • Sensitivity and Specificity


  • Biphenyl Compounds
  • Lignans
  • magnolol
  • honokiol