N-glucuronidation reactions. III. Regioselectivity of N-glucuronidation of methylbiphenyl tetrazole, methylbiphenyl triazole, and methylbiphenyl imidazole using human and rat recombinant UDP-glucuronosyltransferases stably expressed in V79 cells

Drug Metab Dispos. 1994 Jul-Aug;22(4):659-62.
No abstract available

MeSH terms

  • Animals
  • Biphenyl Compounds / metabolism*
  • Cell Line
  • Enzyme Stability
  • Fibroblasts / enzymology
  • Glucuronates / metabolism*
  • Glucuronosyltransferase / genetics
  • Glucuronosyltransferase / metabolism*
  • Humans
  • Imidazoles / metabolism*
  • Isoenzymes / genetics
  • Isoenzymes / metabolism*
  • Isomerism
  • Lung / cytology
  • Lung / enzymology
  • Microsomes, Liver / enzymology
  • Rats
  • Recombinant Proteins / genetics
  • Recombinant Proteins / metabolism
  • Substrate Specificity
  • Tetrazoles / metabolism*
  • Triazoles / metabolism*

Substances

  • Biphenyl Compounds
  • Glucuronates
  • Imidazoles
  • Isoenzymes
  • Recombinant Proteins
  • Tetrazoles
  • Triazoles
  • Glucuronosyltransferase