Varicella and thrombotic complications associated with transient protein C and protein S deficiencies in children

Eur J Pediatr. 1994 Sep;153(9):646-9. doi: 10.1007/BF02190684.


We report six cases of protein S deficiency secondary to varicella. Five cases were complicated by thrombotic and vascular events, namely purpura fulminans and necrotic vasculitis, deep vein thrombosis and stroke. Two cases were associated with protein C deficiency and one case revealed a heterozygous factor XII deficiency. The underlying mechanism of this acquired protein S deficiency is unclear but could be related to a direct effect of zoster virus.

Publication types

  • Case Reports

MeSH terms

  • Chickenpox / complications*
  • Child
  • Child, Preschool
  • Disseminated Intravascular Coagulation / complications
  • Factor XII Deficiency / complications
  • Female
  • Humans
  • Male
  • Protein C Deficiency*
  • Protein S Deficiency / complications*
  • Purpura / complications*
  • Thrombosis / complications*
  • Time Factors
  • Vasculitis / complications*