Cross-reactivity between an HLA-B27-derived peptide and a retinal autoantigen peptide: a clue to major histocompatibility complex association with autoimmune disease

Eur J Immunol. 1994 Nov;24(11):2579-85. doi: 10.1002/eji.1830241103.


Statistical correlations between the expression of various HLA antigens and certain autoimmune diseases have been observed for both HLA class I and II antigens. Autoimmune diseases like spondyloarthropathies and anterior uveitis are associated with HLA-B27, but uveitis in Behçet's disease with HLA-B51. We describe a peptide from disease-associated HLA class I antigens sharing sequence homologies with a highly uveitogenic epitope from the retinal autoantigen S-antigen. S-antigen induces autoimmune uveitis in the animal model and is a major autoantigen in human disease. The HLA peptide induced uveitis in the Lewis rat and, moreover, suppressed S-antigen-induced disease when administered orally. Patients' PBL cross-reacted with the HLA- and corresponding retinal peptide, explaining the organ specificity of the disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens / immunology*
  • Arrestin
  • Autoantigens / immunology*
  • Autoimmune Diseases / etiology*
  • Cross Reactions
  • Eye Proteins / immunology*
  • HLA-B27 Antigen / immunology*
  • Humans
  • Immune Tolerance
  • Immunization
  • Lymphocytes / immunology
  • Molecular Sequence Data
  • Rats
  • Rats, Inbred Lew
  • Sequence Homology, Amino Acid
  • Uveitis / etiology*
  • Uveitis / immunology


  • Antigens
  • Arrestin
  • Autoantigens
  • Eye Proteins
  • HLA-B27 Antigen