Genetic control of the human V beta 13.2 T cell repertoire: importance of allelic variation outside the coding regions of the TCRBV13S2 gene

Eur J Immunol. 1994 Nov;24(11):2863-7. doi: 10.1002/eji.1830241142.


In humans, the T cell repertoire is influenced by HLA, T cell receptor null alleles and antigen. Here, we describe a novel mechanism, independent of superantigen or T cell receptor structure which influences the T cell repertoire in a V beta-dependent manner. We have identified a biallelic locus, the TCRBV13S2 T cell receptor gene, where allelic differences predominate in the non-coding regions including transitions, transversions and frameshift deletions. The expressed protein is non-polymorphic at this locus. The TCRBV13S2 genotype profoundly influences the circulating levels of V beta 13.2 CD4 T cells but does not affect T cell receptor expression or function.

MeSH terms

  • Alleles*
  • Base Sequence
  • Chromosome Mapping*
  • Genotype
  • Humans
  • Molecular Sequence Data
  • Receptors, Antigen, T-Cell, alpha-beta / analysis
  • Receptors, Antigen, T-Cell, alpha-beta / genetics*
  • Receptors, Antigen, T-Cell, alpha-beta / physiology


  • Receptors, Antigen, T-Cell, alpha-beta

Associated data

  • GENBANK/X75418
  • GENBANK/X75419